Endocrine Abstracts

Objectives: Insulin interacts with the GH – insulin-like growth factor (IGF) system by a reciprocal regulation of IGF-binding proteins (IGFBPs) and GH, which in turn interact to regulate insulin sensitivity (IS). We previously showed that IGFBP-2 is involved in the insulin-induced reduction in IGF1 bioactivity. We here address the modulation of IGF1 bioactivity during acute lipid-induced insulin resistance.Methods: 18 healthy men (30.8±2.6 year...